Missense mutation

Missense Mutation is a type of point mutation. It is where single nucleotides are changed to cause substitution of different amino acids. That can render the resulting protein nonfunctional.This mutation is responsible for Epidermolysis bullosa, and sickle cell disease. Not all Missense Mutations lead to major protein changes. With a Missense Mutation, the new nucleotide alters the codon so as to produce an altered amino acid in the protein product.